SrasV1, Main, Exploration, bibRecord, 005363

Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design.

Identifieur interne : 005363 ( Main/Exploration ); précédent : 005362; suivant : 005364

Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design.

Auteurs : Mayuko Takeda-Shitaka [Japon] ; Hiroyuki Nojima ; Daisuke Takaya ; Kazuhiko Kanou ; Mitsuo Iwadate ; Hideaki Umeyama

Source :

Chemical & pharmaceutical bulletin [ 0009-2363 ] ; 2004.

RBID : pubmed:15133227

Descripteurs français

KwdFr :
- Antiviraux (synthèse chimique), Conception de médicament, Cysteine endopeptidases, Endopeptidases (), Modèles moléculaires, Protéines virales (), Relation structure-activité, Similitude structurale de protéines, Virus du SRAS (enzymologie), Évaluation préclinique de médicament ().
MESH :
- enzymologie : Virus du SRAS.
- synthèse chimique : Antiviraux.
- Conception de médicament, Cysteine endopeptidases, Endopeptidases, Modèles moléculaires, Protéines virales, Relation structure-activité, Similitude structurale de protéines, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Cysteine Endopeptidases, Drug Design, Drug Evaluation, Preclinical (methods), Endopeptidases (chemistry), Models, Molecular, SARS Virus (enzymology), Structural Homology, Protein, Structure-Activity Relationship, Viral Proteins (chemistry).
MESH :
- chemical , chemical synthesis : Antiviral Agents.
- chemical , chemistry : Endopeptidases, Viral Proteins.
- chemical : Cysteine Endopeptidases.
- enzymology : SARS Virus.
- methods : Drug Evaluation, Preclinical.
- Drug Design, Models, Molecular, Structural Homology, Protein, Structure-Activity Relationship.

Abstract

To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design.

DOI: 10.1248/cpb.52.643
PubMed: 15133227

Affiliations:

Le document en format XML

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<author><name sortKey="Takaya, Daisuke" sort="Takaya, Daisuke" uniqKey="Takaya D" first="Daisuke" last="Takaya">Daisuke Takaya</name>
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<author><name sortKey="Kanou, Kazuhiko" sort="Kanou, Kazuhiko" uniqKey="Kanou K" first="Kazuhiko" last="Kanou">Kazuhiko Kanou</name>
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<author><name sortKey="Iwadate, Mitsuo" sort="Iwadate, Mitsuo" uniqKey="Iwadate M" first="Mitsuo" last="Iwadate">Mitsuo Iwadate</name>
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<author><name sortKey="Umeyama, Hideaki" sort="Umeyama, Hideaki" uniqKey="Umeyama H" first="Hideaki" last="Umeyama">Hideaki Umeyama</name>
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<term>Endopeptidases (chemistry)</term>
<term>Models, Molecular</term>
<term>SARS Virus (enzymology)</term>
<term>Structural Homology, Protein</term>
<term>Structure-Activity Relationship</term>
<term>Viral Proteins (chemistry)</term>
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<term>Similitude structurale de protéines</term>
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<front><div type="abstract" xml:lang="en">To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design.</div>
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Serveur d'exploration SRAS

Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design.

Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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